Bottle Size: 60 caps
Pill Size: 200 mg
Indole-3-Carbinol: To support estrogen metabolism*
• Maintains optimal 2-hydroxy/16-hydroxy estrogen ratios*
• Found in cabbage family vegetables, it’s a source of DIM
• Nutritional support for liver detoxification*
• Made without flowing agents that can inhibit bioavailability
Thorne Research Indole-3-Carbinol Benefits
Indole-3-carbinol (I3C) is a compound found in high concentrations in vegetables of the Brassica family, including broccoli, cauliflower, Brussels sprouts, and cabbage.
As a dietary supplement, I3C provides key nutritional support for liver detoxification.* It also plays an important role in supporting female reproductive health.* The majority of ingested I3C is absorbed in the small intestine as diindolylmethane (DIM), which is thought to be the primary contributor to I3C’s beneficial properties. DIM has been shown to selectively bind to estrogen receptors and may act as an estrogen antagonist at physiological concentration.*
In the liver, I3C promotes the metabolism of estrogen and increases the ratio of 2-hydroxy estrogen to 16-hydroxy estrogen.* The 2-hydroxy estrogens, less active than the 16-hydroxy estrogens, generally are eliminated more rapidly from the body. One prospective study found postmenopausal women with the most favorable urinary 2:16-hydroxyestrone ratio were most likely to maintain good female health.*
Preliminary studies have examined the efficacy, safety, and optimal supplementation of I3C. A 12-week phase I trial conducted on 17 women found a 66-percent increase in urinary 2:16-hydroxyestrone ratio with administration of 400 mg I3C daily.*
Thorne Research Indole-3-Carbinol Ingredients
Indole-3-Carbinol / Diindolylmethane (DIM) complex 200 mg.
Other Ingredients: Hypromellose (derived from cellulose) capsule, Microcrystalline Cellulose, Leucine, Silicon Dioxide. (See manufacturer’s warnings at iHerb.)
Thorne Research Indole-3-Carbinol Side Effects
Indole-3-Carbinol is safe for most users. A search of “Indole-3-Carbinol side effects” and “Indole-3-Carbinol reviews” revealed these possible side effects for some users: Skin rashes and small increases in liver enzymes. To avoid possible side effects, start with a small dose, and gradually increase to the recommended dosage. Always consult your doctor before taking any supplement.
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